Abstract Genome editing using CRISPR-Cas systems is a promising avenue for the treatment of genetic diseases.However, cellular and humoral immunogenicity of genome editing tools, which originate from bacteria, complicates their clinical use.Here we report reduced immunogenicity (Red)(i)-variants of two clinically relevant nucleases, SaCas9 and AsCa
Dynamic visual simulation of flood risk is crucial for scientific and intelligent emergency management of flood disasters, in which data quality, availability, visualization, and interoperability are important.Here, a seamless integration of a spatio-temporal Geographic Information System (GIS) with one-dimensional (1D) and two-dimensional Speed Se
Abstract Cosmetic Bag Currently, notalgia paresthetica (NP) is a poorly-understood condition diagnosed on the basis of pruritus, pain, or both, in the area medial to the scapula and lateral to the thoracic spine.It has been proposed that NP is caused by degenerative changes to the T2-T6 vertebrae, genetic disposition, or nerve entrapment of the pos
Dr.Jie Zhang, a distinguished physicist, has made significant contributions in the fields of high-energy-density physics and inertial confinement fusion.Because of these, he Xbox was elected academician of the Chinese Academy of Sciences in 2003, academician of the German National Academy of Sciences in 2007, Fellow of the Academy of Sciences for t